otitis media with effusion in children and the impact of risk factors on serum cytokine levels

Authors

saba arshi department of allergy and clinical immunology, iran university of medical sciences, tehran, iran.

fatemeh dehghani-firouzabadi ent and head and neck research center and department, hazrat rasoul akram hospital, iran university of medical sciences,tehran,iran.

babak ghalehbaghi ent and head and neck research center and department, hazrat rasoul akram hospital, iran university of medical sciences,tehran,iran.

ali dehghani-firouzabadi department of health, epidemiologist, mississippi state, united states.

abstract

introduction:to evaluate the role of allergic-type and infectious-type cytokines in children with chronic otitis media with effusion (ome) materials and methods:we investigated serum levels of interleukins (il)-4, il-5, and il-13, along with interferon-gamma (ifn-γ) and tumor necrosis factor-alpha (tnf-α), by enzyme-linked immunosorbent assay (elisa) in 35 children with ome and 28 healthy controls. results:children with ome had significantly higher levels of il-5 in comparison with the control group, ranging from 1 pg/ml in cases to 0.04 pg/ml in controls (p=0.009). however, after adjusting for confounding variables, there was no significant difference in serum levels of il-13, il-4, ifn-γ, or tnf-α between the two groups (p=0.287, p=0.627, p=0.793, and p=0.217, respectively) conclusions:the findings of this study suggest that in comparison with the control group, serum il-5 levels were elevated in ome cases.

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Journal title:
iranian journal of otorhinolaryngology

جلد ۲۹، شماره ۲، صفحات ۷۵-۸۱

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